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You may have encountered keyboards with an optional lift at the back of the board, raising the top keys higher than the space bar. Every set of hands is different, but for most people, pulling the backs of the hands towards the forearms increases strain. Negative tilt has the opposite effect by sloping in the other direction, lowering the top number keys while raising the edge with the spacebar. Many Alice and some split keyboards offer an optional negative tilt. I found it was more comfortable to enable that feature when I’m standing, and I preferred to have the keys flat when sat at my desk.